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Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial

Researchers Edmund Juszczak, Jennifer Bell and Andrew King from the NPEU Clinical Trials Unit have collaborated in researching the analgesic efficacy and safety of oral morphine used during procedures that cause premature infants pain (The Poppi Trial). Their findings have recently been published in a paper by Caroline Hartley et. al.  For full details of the methods used and thier findings, please read the article in the The Lancet.

The Poppi trial team joins the #startedinoxford initiative

The Poppi trial team have joined the #startedinoxford initiative with a video introducing their work to explore how babies feel pain.

Started in Oxford highlights some of the innovative and exciting work being undertaken at the University of Oxford. Further details about this initiative can be found on the Started in Oxford youtube channel here

Top recruitment for Poppi team

The Poppi team have broken their record by recruiting a fantastic 9 participants in September! With a previous monthly record of 6, the team have made an outstanding achievement.

Thank you to the Poppi team at the JR for all your hard work, and many thanks to all the families who have taken part.

The Poppi trial now has 29 recruits.

‘From agony to analgesia: seeing pain’ – Poppi investigators interviewed on BBC Radio 4

Poppi investigators Dr Rebeccah Slater and Dr Fiona Moultrie recently featured in a BBC Radio 4 programme entitled ‘From Agony to Analgesia’. The episode, ‘Seeing Pain’, was broadcast on 16th August 2017 and explored current research in the field of pain, including areas such as pain measurement in premature babies, phantom limb syndrome and chronic pain. Dr Slater and Dr Moultrie explain current approaches used to measure pain in babies, and the possibility of using brain activity as a new measure of pain. In particular, they discuss how pain could be determined specifically in premature babies in the context of the Poppi trial. The full radio programme can be accessed at

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The Poppi trial is funded by The Wellcome Trust and the NIHR EME Programme.

NIHR acknowledgment and disclaimer: This study is funded by the National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme (Reference Number 14/187/01). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.