A special communication describing an extension to the Consolidated Standards of Reporting Trials (CONSORT) has been published in the Journal of the American Medical Association (JAMA). Led by NPEU CTU Director and Associate Professor Ed Juszczak, the extension aims to provide greater transparency and accuracy in reporting of such trials, to enhance understanding of the methodology and allow readers to accurately assess the conduct of a trial and interpret the results.
This extension to the CONSORT 2010 statement checklist will enhance the reporting of multi-arm trials, and has an important educational role in improving their conduct. It therefore covers the overlapping areas of multi-arm trial methodology and reporting.
Among the recommendations of the extension are that multi-arm trials be identified as such by the authors and that clear objectives and hypotheses referring to all the treatment groups be stated. If periods of recruitment and follow-up are different across groups, these should be explained, along with the statistical implications.
The prestigious British Medical Journal (BMJ) have awarded the UK Research Paper of the Year 2018 to the BUMPES trial team. The BMJ Awards, now in its 10th year, showcases excellence and inspirational contributions in healthcare. The paper “Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial“, published in the BMJ in October 2017, was winner of the category which recognises new UK-based research which is likely to have a great impact on improving health and healthcare. The trial and writing committee, the Epidural and Position Trial Collaborative led by Professor Peter Brocklehurst, includes the NPEU Clinical Trials Unit director, Edmund Juszczak, senior trials statistician, Pollyanna Hardy, and senior health economist, Oliver Rivero-Arias. Read more.
The NPEU Clinical Trials Unit (CTU) has been awarded full CTU registration by the UK Clinical Research Collaboration (UKCRC). The Review Committee noted that the application submitted for the 2017 registration call “provided clear evidence of operational experience in the design and delivery of large scale multicentre clinical trials.” The committee concluded “a strong application had been presented from a very good free standing unit which met the criteria for Full Registration”. Our congratulations go out to the entire NPEU CTU team.
Associate Professor Ed Juszczak and Senior Statistician Louise Linsell will be at the 8th Europaediatrics Congress in Bucharest, Romania from 7-10 June 2017. On 8 June, Ed will give a talk entitled: Basic Steps in Clinical Trial Design and on 9 June, Louise will present the latest results from the EPICure study, Born at the Threshold of Viability: Impact on Cognitive Development into Adulthood. If you attend the conference, please come and say hello! Do also look out for two articles related to Louise’s work that focus on cognitive and behavioural trajectories in the EPICure cohort. These articles should be published soon.