The NPEU Clinical Trials Unit was established more than 40 years ago as a specialist clinical trials unit focussing on perinatal research. In this time we have conducted a large number of trials, particularly within obstetric and neonatal medicine. Individual trial webpages for our current portfolio are accessible by using the links below. You can also view details of all our trials and their publications or find all NPEU publications, including those from the NPEU Clinical Trials Unit, on the NPEU publications page.
Trials in Set-up
The BASE Trial: Bicarbonate for AcidosiS in very pretErm babies, a randomised clinical trial
The neoGASTRIC trial: Avoiding routine gastric residual volume measurement in neonatal critical care, a multi-centre, randomised controlled trial
Treating Oesophageal Atresia to prevent Stricture: A multicentre, randomised trial of gastric acid suppression medication for treating oesophageal atresia to prevent stricture.
Developmental Outcome of Long-Term Feed Supplementation in Neonates: does nutritional supplementation improve cognitive outcomes for preterms and infants with hypoxic ischaemic encephalopathy?
Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of Preterm Infants at Birth: Does a high, dynamic PEEP strategy to support the lung improve outcomes in extremely preterm infants?
SURFactant Or Not: randomised controlled trial of early surfactant therapy versus expectant management in late preterm and early term infants with respiratory distress.
Outcome after Selective Early Closure of Ductus Arteriosus in Extremely Preterm Babies: does treatment of Patent Ductus Arteriosus with ibuprofen improve outcomes at 36 weeks postmenstrual age?
EXpressing in PREmaturity – Simple interventionS: Does a guided relaxation audio track increase yield of expressed milk in mothers of very preterm infants?
Analysis & Dissemination
Antiseptic Randomised Controlled Trial for Insertion of Catheters: comparing two topical antiseptic solutions used prior to percutaneous central venous catheter insertion in preterm neonates.
Freezing of embryos in assisted conception: evaluating clinical and cost-effectiveness of freezing embryos followed by thawed frozen embryo transfer, compared with fresh embryo transfer, in women undergoing IVF.
A randomised controlled trial of FRenotomy and breastfeeding support Or breastfeeding Support without frenotomy to investigate continuation of breastfeeding for babies with Tongue-TIE.
NeoCLEAR: Neonatal Champagne Lumbar punctures Every time - An RCT. A multicentre, randomised controlled 2x2 factorial trial to investigate techniques to increase lumbar puncture success.
Pre-eclampsia in HOspital: Early iNductIon or eXpectant management: Does delivery in women with pre-eclampsia at 34 to 36 weeks gestation reduce maternal complications compared to expectant management?
Timing of Stoma Closure in Neonates: A study to assess feasibility of performing a randomised controlled trial comparing early and late stoma closure in neonates.
WithHolding Enteral feeds Around packed red cell Transfusion to prevent necrotising enterocolitis in preterm neonates: A multi-centre, electronic patient record, randomised controlled pilot trial.