Trials Portfolio
Trials in Set-up
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Developmental Outcome of Long-Term Feed Supplementation in Neonates: does nutritional supplementation improve cognitive outcomes for preterms and infants with hypoxic ischaemic encephalopathy? -
Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of Preterm Infants at Birth: Does a high, dynamic PEEP strategy to support the lung improve outcomes in extremely preterm infants? -
Treating Oesophageal Atresia to prevent Stricture: A multicentre, randomised trial of gastric acid suppression medication for treating oesophageal atresia to prevent stricture.
Recruiting Trials
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EXpressing in PREmaturity – Simple interventionS: Does a guided relaxation audio track increase yield of expressed milk in mothers of very preterm infants? -
SURFactant Or Not: randomised controlled trial of early surfactant therapy versus expectant management in late preterm and early term infants with respiratory distress. -
Timing of Stoma Closure in Neonates: A study to assess feasibility of performing a randomised controlled trial comparing early and late stoma closure in neonates.
Analysis & Dissemination
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Antiseptic Randomised Controlled Trial for Insertion of Catheters: comparing two topical antiseptic solutions used prior to percutaneous central venous catheter insertion in preterm neonates. -
Freezing of embryos in assisted conception: evaluating clinical and cost-effectiveness of freezing embryos followed by thawed frozen embryo transfer, compared with fresh embryo transfer, in women undergoing IVF. -
A randomised controlled trial of FRenotomy and breastfeeding support Or breastfeeding Support without frenotomy to investigate continuation of breastfeeding for babies with Tongue-TIE. -
NeoCLEAR: Neonatal Champagne Lumbar punctures Every time - An RCT. A multicentre, randomised controlled 2x2 factorial trial to investigate techniques to increase lumbar puncture success. -
Pre-eclampsia in HOspital: Early iNductIon or eXpectant management: Does delivery in women with pre-eclampsia at 34 to 36 weeks gestation reduce maternal complications compared to expectant management? -
WithHolding Enteral feeds Around packed red cell Transfusion to prevent necrotising enterocolitis in preterm neonates: A multi-centre, electronic patient record, randomised controlled pilot trial.
Supported Trials
Non-NPEU trials supported by the NPEU Clinical Trials Unit.
Trials Archive
Archive of NPEU trials.