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E-Freeze results published

in Human Reproduction show no evidence to suggest that freezing embryos and then transferring at a later date leads to a higher chance of having a healthy baby than fresh embryo transfer

View E-Freeze publications

ANODE Trial - winner of BMJ Awards 2020: Research paper of the year

Our Trials

The NPEU Clinical Trials Unit was established more than 40 years ago as a specialist clinical trials unit focussing on perinatal research. In this time we have conducted a large number of trials, particularly within obstetric and neonatal medicine. Individual trial webpages for our current portfolio are accessible by using the links below. You can also view details of all our trials and their publications or find all NPEU publications, including those from the NPEU Clinical Trials Unit, on the NPEU publications page.

Explore all our current and previous trials and their publications

Trials in Set-up

The BOBBi Trial: Better Outcomes in Babies with Bacterial meningitis, a randomised controlled trial

Treating Oesophageal Atresia to prevent Stricture: A multicentre, randomised trial of gastric acid suppression medication for treating oesophageal atresia to prevent stricture.

Recruiting Trials

The BASE Trial: Bicarbonate for AcidosiS in very pretErm babies, a randomised clinical trial

The Monoclonal Antibody Medications in inflammatory Arthritis: stopping or continuing in pregnancy (MAMA) trial

The neoGASTRIC trial: Avoiding routine gastric residual volume measurement in neonatal critical care, a multi-centre, randomised controlled trial

Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of Preterm Infants at Birth: Does a high, dynamic PEEP strategy to support the lung improve outcomes in extremely preterm infants?

Follow-up

Developmental Outcome of Long-Term Feed Supplementation in Neonates: does nutritional supplementation improve cognitive outcomes for preterms and infants with hypoxic ischaemic encephalopathy?

Analysis & Dissemination

Outcome after Selective Early Closure of Ductus Arteriosus in Extremely Preterm Babies: does treatment of Patent Ductus Arteriosus with ibuprofen improve outcomes at 36 weeks postmenstrual age?

Freezing of embryos in assisted conception: evaluating clinical and cost-effectiveness of freezing embryos followed by thawed frozen embryo transfer, compared with fresh embryo transfer, in women undergoing IVF.

EXpressing in PREmaturity – Simple interventionS: Does a guided relaxation audio track increase yield of expressed milk in mothers of very preterm infants?

NeoCLEAR: Neonatal Champagne Lumbar punctures Every time - An RCT. A multicentre, randomised controlled 2x2 factorial trial to investigate techniques to increase lumbar puncture success.

SURFactant Or Not: randomised controlled trial of early surfactant therapy versus expectant management in late preterm and early term infants with respiratory distress.

WithHolding Enteral feeds Around packed red cell Transfusion to prevent necrotising enterocolitis in preterm neonates: A multi-centre, electronic patient record, randomised controlled pilot trial.