Severe respiratory virus infection in pregnancy and participating in the RECOVERY Trial
Key points
- Pregnant women are eligible to be recruited to most arms of the RECOVERY Trial.
- Observational pregnancy outcomes data has previously been collected for pregnant RECOVERY participants through the UKOSS Covid-19 in pregnancy study.
- This study will allow for the continued collection of pregnancy outcome data for pregnant women participating in the RECOVERY trial.
Surveillance period
1st April 2022 – 31st March 2024
Background
The RECOVERY Trial is an international clinical trial which aims to identify effective treatments for those hospitalised with Covid-19(1). Pregnant women are known to be at risk of severe infection with respiratory virus, and have been eligible to be recruited to most arms of the RECOVERY trial. Observational pregnancy outcome data for previous RECOVERY participants was collected through the UKOSS Covid-19 study and their outcomes compared with the cohort of women with Covid-19 as a whole. These detailed pregnancy data also describe their characteristics and management including other aspects of care for severe respiratory infection in pregnancy. The purpose of this study is to allow for the continued collection of observational pregnancy outcome data going forward as RECOVERY opens new arms to women with other severe respiratory infections, including influenza, to describe their characteristics and management including other aspects of care for severe respiratory infection in pregnancy and to compare their outcomes with previously collected UKOSS information on women with seasonal influenza or Covid-19 in pregnancy.
Objective
To use the UK Obstetric Surveillance System (UKOSS) to describe the incidence, risk factors, current management and outcomes of pregnant women participating in the RECOVERY Trial.
Research questions
- What is the incidence of pregnant women participating in the RECOVERY Trial in the UK?
- What are the maternal and neonatal outcomes of pregnancy in women who have participated in the RECOVERY Trial?
Case definition
Any woman admitted to hospital in pregnancy and participating in the RECOVERY Trial.
Funding
This study is supported by the portfolio funders to the RECOVERY trial.
Ethics committee approval
This study has been approved by the North London Brent REC (Ref. Number: 10/H0717/20).
Lead investigator
Prof. Marian Knight, National Perinatal Epidemiology Unit, University of Oxford
Sample Data Collection Form
References
