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Record month for Minidex!

Fantastic effort from the whole Minidex team this January, we have broken the Minidex recruitment record with 5 participants this month! This brings the recruitment total up to 17. Thank you to all the families who agreed to take part, and particular congratulations to the site teams in Coventry, Hull, Leicester, Leeds and Preston – keep up the great work!

First recruit for the Minidex trial

Congratulations to the team at Liverpool Women’s Hospital, led by Minidex Chief Investigator Dr Mark Turner, who have recruited the first participant to the Minidex trial!

Many thanks to the family for agreeing to take part.

The trial launched on 21st July and now has eight open sites: Liverpool Women’s Hospital, Birmingham Women’s Hospital, Leicester Royal Infirmary, Royal Hallamshire Hospital, University Hospital of North Tees, University Hospital Coventry, Hull Royal Infirmary and Royal Preston Hospital.

We plan to open the remaining three recruiting sites by the end of August (Bradford Royal Infirmary, Royal Victoria Infirmary and Leeds General Infirmary). The first participant was recruited on 2nd August – well done Liverpool!

Minidex opens for recruitment

Despite all the challenges, the Minidex trial has finally launched and is open for recruitment! A huge thank you to all of the site teams for your patience and hard work – well done. The Minidex trial is now recruiting at Birmingham Women’s Hospital and Leicester Royal Infirmary with nine more sites to follow suit shortly. We are hopeful that we will receive our first recruit very soon!

Can low dose dexamethasone improve lung function for preterm babies?

Chronic lung disease is an ongoing challenge for neonatal medicine, affecting around 1450 preterm babies every year in the UK. High doses of dexamethasone (a corticosteroid) have been shown to improve lung function, but may be associated with longer term neurodevelopmental problems. The effectiveness of lower doses of dexamethasone is unknown.

Dr Helen Yates, lead clinician for the Minidex trial, has recently published an article exploring this controversial topic and discussing the role of the Minidex trial in resolving this debate. The Minidex trial will examine the efficacy of very low dose dexamethasone therapy, to explore whether a minimal dose can still provide improvements in lung function without the short term side effects associated with standard dose therapy. Read the abstract.

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This study is funded by the National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme (Reference Number 13/158/48). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.

Funding Acknowledgement: the Minidex trial is funded by the National Institute for Health Research EME Programme.