E-Freeze

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Freezing of embryos in assisted conception: a randomised controlled trial evaluating the clinical and cost-effectiveness of a policy of freezing embryos followed by thawed frozen embryo transfer, compared with a policy of fresh embryo transfer in women undergoing in vitro fertilisation.

Trial started: 2015 Trial ended: 2019

Show Publications

Yangmei Li, Jenny McLeish, Pollyanna Hardy, Christina Cole, Claire Carson, Fiona Alderdice, Abha Maheshwari, Anxiety in couples undergoing IVF: evidence from E-Freeze randomised controlled trial, Human Reproduction Open, Volume 2024, Issue 3, 2024, hoae037
https://doi.org/10.1093/hropen/hoae037
Maheshwari A, Bell JL, Bhide P, Brison D, Child T, Chong HY, et al. Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze). Hum Reprod. 2022;37(3):476-87.
https://doi.org/10.1093/humrep/deab279
Maheshwari A, Bari V, Bell JL, Bhattacharya S, Bhide P, Bowler U, Brison D, Child T, Chong HY, Cheong Y, Cole C, Coomarasamy A, Cutting R, Goodgame F, Hardy P, Hamoda H, Juszczak E, Khalaf Y, King A, Kurinczuk JJ, Lavery S, Lewis-Jones C, Linsell L, Macklon N, Mathur R, Murray D, Pundir J, Raine-Fenning N, Rajkohwa M, Robinson L, Scotland G, Stanbury K, Troup S. Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT. Health Technol Assess. 2022;26(25):1-142.
https://doi.org/10.3310/AEFU1104
Bell JL, Hardy P, Greenland M, Juszczak E, Cole C, Maheshwari A, Bhattacharya S, Linsell L. E-Freeze - a randomised controlled trial evaluating the clinical and cost effectiveness of a policy of freezing embryos followed by thawed frozen embryo transfer compared with a policy of fresh embryo transfer, in women undergoing in vitro fertilisation: a statistical analysis plan. Trials. 2020;21(1):596.
https://doi.org/10.1186/s13063-020-04441-9

Published Protocol

Maheshwari A, Bhattacharya S, Bowler U, Brison D, Child T, Cole C, et al. Study protocol: E-freeze - freezing of embryos in assisted conception: a randomised controlled trial evaluating the clinical and cost effectiveness of a policy of freezing embryos followed by thawed frozen embryo transfer compared with a policy of fresh embryo transfer, in women undergoing in vitro fertilisation. Reprod Health. 2019;16(1):81. DOI: 10.1186/s12978-019-0737-2

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E-FREEZE Participant Communication

E-FREEZE Results Infographic

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