Publication of guidance on managing changes to participants’ involvement in clinical trials

Published on Tuesday, 15 July 2025

The NPEU Clinical Trials Unit's recent article on managing participant withdrawal and changes of consent in clinical trials (www.npeu.ox.ac.uk/ctu/news/2696-participant-withdrawal-from-a-study-what-it-really-means-and-how-to-manage-it) referred to the PeRSEVERE project (PRincipleS for handling end-of-participation EVEnts in clinical trials Research) (persevereprinciples.org), initiated within the UKCRC Registered Clinical Trials Unit Network.

As outlined in that article, this developed a series of principles which can be used as guidance for anyone involved in managing participant changes in consent. The paper documenting the PeRSEVERE work has now been published and can be accessed here. It includes an outline of how the principles were developed and how concerns and queries from stakeholders were taken into account.