Publications and key documentation
Baby-OSCAR NIHR Report
Date published: 2026
Gupta S, Subhedar NV, Bell JL, Bowler U, Clarke C, Cole C, et al. Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial (Baby-OSCAR trial). Health Technol Assess. 2026;30(11).
Baby-OSCAR Long-term Outcomes Publication
Date published: 2025
Gupta S, O'Connor H, Juszczak E, Subhedar NV, Bowler U, Clarke C, et al. Two-year outcomes after selective early treatment of patent ductus arteriosus with ibuprofen in preterm babies: follow-up of Baby-OSCAR–a randomised controlled trial. eClinicalMedicine. 2025;87:103424.
Baby-OSCAR Health Economics Outcomes Publication
Date published: 2025
Ogwulu CB, Monahan M, Gupta S, Subhedar NV, Bell JL, Field D, et al. Economic Evaluation alongside the Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen in Extreme Preterm Babies. medRxiv. 2025.
Baby-OSCAR Short-term Outcomes Publication
Date published: 2024
Gupta S, Subhedar NV, Bell JL, Field D, Bowler U, Hutchison E, et al. Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen. N Engl J Med. 2024;390(4):314-25.
Baby-OSCAR Long-term Statistical Analysis Plan
Date published: 2023
The Statistical Analysis Plan for the Long Term Outcomes was finalised and sign in April 2023. For further detail please see:
Baby-OSCAR Protocol Publication
Date published: 2021
Gupta S, Juszczak E, Hardy P, Subhedar N, Wyllie J, Kelsall W, et al. Study protocol: baby-OSCAR trial: Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial. BMC Pediatr. 2021;21(1):100.
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-021-02558-7
Baby-OSCAR Statistical Analysis Plan Publication
Date published: 2021
Bell JL, Gupta S, Juszczak E, Hardy P, Linsell L. Baby-OSCAR: Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies-a statistical analysis plan for short-term outcomes. Trials. 2021;22(1):368.
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05324-3
