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TOBY Children Study - School age outcomes following a newborn cooling trial

Principal investigator
Denis Azzopardi (Hammersmith Hospital, Imperial College, London)
Andrew Whitelaw (University of Bristol), Marianne Thoresen (St Michael's Hospital, Bristol), Neil Marlow (University College London), Malcolm Levene (University of Leeds), Henry Halliday (Queen's University of Belfast), David Edwards (Imperial College, London), Peter Brocklehurst (NPEU), Ed Juszczak (NPEU)
Care of the compromised term infant, Child health and development
Medical Research Council
Start year
End year
NPEU Contact
Ann Kennedy


The aim of this study is to determine the effects of therapeutic hypothermia following perinatal asphyxia on neurological and neuropsychological outcomes at age 6-7 years and also to assess academic attainment and any additional health, societal or educational costs associated with changes in outcome as a result of the intervention. This study will determine whether the apparent initial benefits of cooling are maintained in the longer term.


Journal Articles