A population-based national study of the surgical outcomes of infants born with duodenal atresia.
- Principal investigator
- Marian Knight (NPEU)
- Collaborators
- Nigel Hall (NPEU (Former member)), Anna-May Long (NPEU (Former member))
- Topics
- Paediatric surgery
- Funder
- National Institute for Health Research
- Start year
- 2016
- End year
- 2019
- NPEU Contact
- Marian Knight
Summary
This study will use BAPS-CASS to conduct a prospective, national observational investigation of the incidence, current management practices and outcomes of infants born with duodenal atresia or stenosis in the UK and Ireland. Any live-born infant with occlusion or narrowing of the duodenum associated with atresia, stenosis, duodenal web or annular pancreas presenting before 44 weeks post-conception will be included. Infants with occlusion of the duodenum caused by congenital bands associated with malrotation, intestinal volvulus, duplication cyst or malignancy will be excluded.
Selected Research Questions
- What is the current incidence of live-born duodenal-atresia or stenosis in the UK or Ireland?
- How are these infants managed?
- What is the incidence of associated abnormalities in live-born infants?
- What is the impact of comorbidity on outcome?
- What are the outcomes for infants managed with and without a trans-anastomotic tube?
- What are the outcomes following different surgical techniques for repair of duodenal atresia or stenosis?