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A population-based national study of the surgical outcomes of infants born with duodenal atresia.

Principal investigator
Marian Knight (NPEU)
Nigel Hall (NPEU (Former member)), Anna-May Long (NPEU (Former member))
Paediatric surgery
National Institute for Health Research
Start year
End year
NPEU Contact
Marian Knight


This study will use BAPS-CASS to conduct a prospective, national observational investigation of the incidence, current management practices and outcomes of infants born with duodenal atresia or stenosis in the UK and Ireland. Any live-born infant with occlusion or narrowing of the duodenum associated with atresia, stenosis, duodenal web or annular pancreas presenting before 44 weeks post-conception will be included. Infants with occlusion of the duodenum caused by congenital bands associated with malrotation, intestinal volvulus, duplication cyst or malignancy will be excluded.

Selected Research Questions

  • What is the current incidence of live-born duodenal-atresia or stenosis in the UK or Ireland?
  • How are these infants managed?
  • What is the incidence of associated abnormalities in live-born infants?
  • What is the impact of comorbidity on outcome?
  • What are the outcomes for infants managed with and without a trans-anastomotic tube?
  • What are the outcomes following different surgical techniques for repair of duodenal atresia or stenosis?