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PRU-MHC: Policy Research Unit in Maternal Health & Care (2010 - 2018)

Baby-OSCAR - Outcome after Selective Early Treatment for Closure of Patent Ductus ARteriosus in Pre-term Babies

The Baby-OSCAR clinical trial is a multicentre randomised placebo-controlled trial of ibuprofen treatment for significant patent ductus arteriosus in preterm infants. The aim is to find out whether or not a confirmed large Patent Ductus Arteriosus (PDA) in very premature babies should be treated with ibuprofen within 72 hours of birth.

The internal pilot phase (assessing the practicalities of trial procedures, the equipoise of clinicians and the willingness of parents to enrol their infants into the study) was successful and ended in December 2015 - the main recruitment phase will roll out to all sites just as soon as drug and matched placebo have been sourced, packaged and released.

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