Louise Linsell

Louise Linsell BSc (Hons), MSc

Profile

Senior Medical Statistician and NIHR Research Fellow

Louise has 20 years experience in research and medical statistics and has recently been awarded an NIHR Doctoral Research Fellowship to undertake a DPhil in Population Health.

Email: louise.linsell@npeu.ox.ac.uk

Biography

Louise joined the NPEU Clinical Trials Unit as a Senior Medical Statistician in 2009 and leads on the design, conduct, analysis and reporting of a portfolio of neonatal and obstetric clinical trials. She manages a team of statisticians and is responsible for all matters related to statistics and methodology. She is a co-investigator on a number of recent grants awarded to the unit and teaches on the MSc in Global Health in the Nuffield Department of Population Health. In 2012 she was awarded a National Institute of Health Research (NIHR) Research Doctoral Fellowship to undertake a DPhil on the neurodevelopment of extremely preterm infants with the EPICURE group at University College London. 

Louise graduated with a BSc (Hons) in Mathematics and Statistics at Newcastle University in 1996, followed by a MSc in Medical Statistics at Leicester University in 1997, and since then has held several research posts. In her first post at the London School of Hygiene and Tropical Medicine, she worked on a vitamin A supplementation trial based in Ghana and a study investigating the causes and transmission of new variant Creutzfeldt Jakob disease, and also contributed to the post-graduate teaching programme. Following this she spent over a year working as a statistician at the Medical Research Council (MRC) Sickle Cell Unit in Jamaica, and as a lecturer at the University of the West Indies.

Louise joined the Department of Public Health at Oxford University in 2002 and since then has worked on a variety of epidemiology studies and clinical trials within the University, including a large Ministry of Defence funded study of veterans exposed to chemical warfare agents at Porton Down. In a joint post with the Cancer Research UK Promoting Early Presentation Group at Kings College London she was also statistical lead for a series of trials evaluating a complex intervention for the early diagnosis of breast cancer. In 2009 she moved to the NPEU Clinical Trials Unit.

Publications

  1. Abbott J., Berrington JE., Boyle E., Dorling JS., Embleton NE., Juszczak E., Leaf AA., Linsell L., Johnson S., McCormick K., McGuire W., Roberts T., Stenson B. The SIFT Study. Speed of increasing milk feeds: a randomised controlled trial (submitted to New England Journal of Medicine).
  2. Linsell L., Johnson S., Wolke, D., O’Reilly H., Morris J., Kurinczuk JJ., Marlow N. Cognitive trajectories from infancy to early adulthood following birth before 26 weeks of gestation: a prospective population-based cohort study (submitted to Archives of Disease in Childhood Fetal & Neonatal edition).
  3. Linsell L., Johnson S., Morris J., Kurinczuk JJ., Marlow N. Trajectories of neurobehavioural problems from childhood to early adulthood following extremely preterm birth: a longitudinal cohort study (submitted to the Journal of Child Psychology and Psychiatry).
  4. Linsell L. and Hardy P. Chapter 15: Statistics in medical research. In: O'Brien and Broughton-Pipkin (editors),  Introduction to Research Methodology for Medical Specialists & Trainees. 3rd edition. RCOG Press, London (in press).
  5. Brocklehurst, P., Field, DJ., Juszczak, E., Kenyon, S., Linsell, L., Newburn, M., Plachcinski, R., Quigley, M., Schroeder, E., Steer, P. The INFANT trial. Lancet 2017: 390; 28.
  6. Linsell L., Malouf R., Morris J., Kurinczuk JJ., Marlow N. Risk factor models for neurodevelopmental outcome in children born very preterm or with very low birth weight: a systematic review of methodology and reporting. The American Journal of Epidemiology 2017: 185(7); 601-612.
  7. Brocklehurst, P., Field, DJ., Greene, KR., Juszczak, E., Kenyon, S., Linsell, L., Mabey, C., Newburn, M., Plachcinski, R., Quigley, M., Schroeder, E., Steer, P. Computerised interpretation of the fetal heart rate during labour: a randomised controlled trial (INFANT). Lancet 2017: 389; 1719-29.
  8. Abbott J., Berrington JE., Bowler U., Boyle E., Dorling JS., Embleton NE., Juszczak E., Leaf AA., Linsell L., Johnson S., McCormick K., McGuire W., Roberts T., Stenson B. The Speed of increasing milk feeds: a randomised controlled trial. BMC Pediatrics 2017: 17(39).
  9. Kaushal A., Ramirez AJ., Warburton F., Forster AS., Linsell L., Burgess C., Tucker L., Omar L., Forbes LJL. A promoting early presentation intervention sustains increased breast cancer awareness in older women for three years: a randomised controlled trial. Journal of Medical Screening 2016: doi: 10.1177/0969141316667408.
  10. Linsell L., Malouf R., Morris J., Kurinczuk JJ., Marlow N. Prognostic factors for cerebral palsy and motor impairment in children born very preterm or very low birth weight: A systematic review. Developmental Medicine & Child Neurology 2016: 58(6); 554-569.
  11. Linsell L., Malouf R., Johnson S., Morris J., Kurinczuk JJ., Marlow N. Prognostic factors for behavioral problems and psychiatric disorders in children born very preterm or very low birth weight: A systematic review. Journal of Developmental and Behavioral Pediatrics 2016: 37(1); 88-102.
  12. Azzopardi D., Robertson NJ., Bainbridge A., Cady E., Charles-Edwards G., Deierl A., Fagiolo G., Franks NP., Griffiths J., Hajnal J. Juszczak E., Kapetanakis B., Linsell L., Maze M., Omar O., Strohm B., Tusor N., Edwards D. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Lancet Neurology 2016: 15(2); 145-153.
  13. Brocklehurst P., Field DJ., Green KR., Juszczak E., Keith RDF., Kenyon S., Linsell L., Mabey C., Mottram LM., Newburn M., Plachcinski R., Quigley MA., Schroder E., Steer P. Study protocol: A study of an intelligent system to support decision making in the management of labour using the cardiotocogram - the INFANT study protocol. BMC Pregnancy and Childbirth 2016: 16(1):10 doi: 10.1186/s12884-015-0780-0.
  14. Linsell L., Malouf R., Morris J., Kurinczuk JJ., Marlow N. Prognostic factors for poor cognitive development in children born very preterm or very low birth weight: A systematic review. JAMA Pediatrics 2015: 169(12); 1162-1172.
  15. Hollowell J., Rowe R., Townend J., Knight M., Li Y., Linsell L., Redshaw M., Brocklehurst P., Macfarlane A. J., Marlow N., McCourt C., Newburn M., Sandall J., Silverton L. The Birthplace in England national prospective cohort study: further analyses to enhance policy and service delivery decision-making for planned place of birth. Health Service and Delivery Research 2015: 3(36); doi 10.3310/hsdr03360.
  16. Li Y., Townend J., Rowe R., Brocklhurst P., Knight M., Linsell L., Macfarlane A., McCourt C., Newburn M., Marlow N., Pasupathy D., Redshaw M., Sandall J., Silverton L., Hollowell J. Perinatal and maternal outcomes in planned home and obstetric unit births in women at 'higher risk' of complications: secondary analysis of the Birthplace national prospective cohort study. British Journal of Obstetrics and Gynaecology 2015: 122(5); 741-753.
  17. Azzopardi D., Strohm B., Marlow N., Brocklehurst P., Deierl A., Eddama O., Goodwin J., Halliday HL., Juszczak E., Kapellou O., Levene M., Linsell L., Omar O., Thoresen M., Tusor N., Whitelaw A., Edwards D., on behalf of the TOBY Study Group . Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes. New England Journal of Medicine 2014: 371(2); 140-149.
  18. Linsell L., Kurinczuk JJ., Marlow N., Morris J., Malouf R. What factors predict the severity of neurodevelopmental outcome in infants born very preterm? PROSPERO 2014: CRD42014006943. Available from http://www.crd.york.ac.uk/PROSPERO/.
  19. Hawton K., Linsell L., Adeniji T., Fazel S. Self-harm and in prisons in England and Wales: prevalence, risk factors and subsequent suicide. Lancet 2013: 383(9925); 1147-1154.
  20. Hollowell J., Pillas D., Linsell L., Knight M., Brocklehurst P. The impact of maternal obesity on intrapartum outcomes in otherwise low risk women: secondary analysis of the Birthplace national prospective cohort study. British Journal of Obstetrics and Gynaecology 2013: 121(3); 343-355.
  21. Field D., Azzopardi  D., Cowan F., Edwards D., Juszczak E., Linsell L., Marlow N., on behalf of the NEST Study Collaborative Group. Neonatal ECMO Study of Temperature (NEST): a randomized controlled trial. Pediatrics 2013: 132(5); e1247-e1256.
  22. Kempley S., Gupta N., Linsell L., Dorling J., McCormick K., Mannix P., MD, Juszczak E., Brocklehurst P., Leaf A., on behalf of the ADEPT Trial Collaborative Group (2013). Feeding infants below 29 weeks’ gestation with abnormal antenatal Doppler: analysis from a randomised controlled trial. Archives of Diseases in Childhood Fetal Neonatal Edition 2013: 99(1); F6-F11.
  23. Barber V., Linsell L., Locock L., Powell L., Shakeshaft C., Lean K., Coleman J., Juszczak E., Brocklehurst P. The role of electronic fetal monitoring during labour on anxiety levels for women taking part in a randomised controlled trial. British Journal of Midwifery 2013: 21(6); 264-272.
  24. Abbott J., Berrington JE., Boyle E., Dorling JS., Embleton NE., Juszczak E., Leaf AA., Linsell L., Johnson S., McCormick K., McGuire W., Roberts T., Stenson B. Early enteral feeding strategies for very preterm infants: current evidence from Cochrane reviews. Archives of Diseases in Childhood Fetal Neonatal Edition 2013: 98; F470-F472.
  25. McGuire W., Abbott J., Berrington J., Dorling J., Embleton N., Heath P., Juszczak E., Linsell L., Oddie S., Richardson G. Lactoferrin immunoprophylaxis for very preterm infants. Archives of Diseases in Childhood Fetal Neonatal Edition 2013: 98; F2-F4.
  26. Leaf A., Dorling J., Kempley S., McCormick K., Mannix P., Linsell L., Juszczak E., Brocklehurst P. ADEPT: a randomised controlled trial of early versus delayed enteral feeding in growth restricted preterm infants with abnormal antenatal Doppler ultrasounds. Pediatrics 2012: 129; e1260-e1268.
  27. Sinclair J., Willmott L., Fitzpatrick R., Burns T., Yiend J. and the IDEA Group. Patients’ experience of dangerous and severe personality disorder services: qualitative interview study. The British Journal of Psychiatry 2012: 200(3); 252–253.
  28. Azzopardi D., Strohm B., Linsell L., Hobson A., Juszczak E., Kurinczuk J., Brocklehurst P., Edwards AD. Implementation of therapeutic hypothermia for perinatal asphyxia encephalopathy in the UK: analysis of national data. PLoS one 2011: 7(6); e38504.
  29. Brocklehurst P., Hardy P., Hollowell J., Linsell L., Macfarlane  A., McCourt C., Marlow N., Newburn M., Petrou S., Puddicombe D. The Birthplace in England national prospective cohort study: perinatal and maternal outcomes by planned place of birth in ‘low risk’ women. British Medical Journal 2011: 343; d7400.
  30. Burns T., Fazel S., Fahy T., Fitzpatrick R., Rogers R., Sinclair J., Linsell L., Doll H., Yiend J. Dangerous Severe Personality Disordered (DSPD) patients: characteristics and comparison with other high-risk offenders. International Journal of Forensic Mental Health 2011: 10(2); 127-136.
  31. Burns T., Yeeles K., Molodynski A., Nightingale H., Vazquez-Montes M., Sheehan K., Linsell L. Pressures to adhere to treatment (‘leverage’) in English mental care. British Journal of Psychiatry 2011: 199(2); 145-150.
  32. Forbes LJ., Linsell L., Atkins L., Burgess C., Tucker L., Omar L., Ramirez AJ. A promoting early presentation intervention increases breast cancer awareness in older women after two years: a randomised controlled trial. British Journal of Cancer 2011: 105; 18-21.
  33. Forbes LJ., McNaughton Nicholls C., Linsell L., Graham J., Tompkins C., Ramirez AJ. Involving users in the design of a randomised controlled trial of an intervention to promote early presentation in breast cancer: qualitative study. BMC Medical Research Methodology 2010: 10; 110.
  34. Linsell L., Forbes LJ., Patnick J., Wardle J., Austoker J., Ramirez AJ. Women’s preferences for the delivery of the NHS Breast Screening Programme in 2009: a cross-sectional survey. Journal of Medical Screening 2010: 17(4); 176-180.
  35. Linsell L., Forbes LJ., Kapari M., Burgess C., Kapari M., Thurnham A., Ramirez AJ. Validation of a measurement tool to assess awareness of breast cancer. European Journal of Cancer 2010: 46(8); 1374-1381.
  36. Linsell L., Forbes LJ., Kapari M., Burgess C., Omar L., Tucker L., Ramirez AJ. A randomised controlled trial of an intervention to promote early presentation of breast cancer in older women: effect on breast cancer awareness. British Journal of Cancer 2009: 101; S40-S48.
  37. Burgess C., Linsell L., Kapari M., Omar L., Michell M., Whelehan P., Richards M., Ramirez AJ. Promoting early presentation in older women with breast cancer: Preliminary evaluation of a one-to-one health professional-delivered intervention. Journal of Psychosomatic Research 2009: 67(5); 377-387.
  38. Carpenter L., Linsell L., Brooks C., Keegan T., Langdon T., Doyle P., Maconochie N., Fletcher T., Nieuwenhuijsen M., Beral V., Venables K. Cancer morbidity in British military veterans included in experimental research into chemical warfare agents at Porton Down. British Medical Journal 2009: 338; b655.
  39. Venables K., Brooks C., Linsell L., Keegan T., Langdon T., Fletcher T., Nieuwenhuijsen M., Maconochie N., Doyle P., Beral V., Carpenter L. Mortality of British military participants in human experimental research into chemical warfare agents at Porton Down. British Medical Journal 2009: 338; b613.
  40. Keegan T., Walker S., Brooks C., Langdon T., Linsell L., Maconochie N., Doyle P., Beral V., Fletcher T., Nieuwenhuijsen M., Carpenter L., Venables K. Exposures recorded for participants in the UK chemical warfare agent human research programme, 1941-89. Annals of Occupational Hygiene 2009: 53(1); 83-97.
  41. Fazel S., Gulati G., Linsell L., Geddes J., Grann M. Schizophrenia and violence: systematic review and meta-analysis. PLoS Medicine 2009: 6(8); e1000120.
  42. Constantinidou A., Afuwape SA., Linsell L., Hung T., Acland K., Healy C., Ramirez AJ., Harries M. Informational needs of patients with melanoma and their views on the utility of investigative procedures International journal of clinical practice 2009: 63(11); 1595-1600.
  43. Linsell L., Burgess C., Cochrane M., Richards M., Ramirez AJ. Breast cancer awareness in older women. British Journal of Cancer 2008: 99; 1221-1225.
  44. Wilkinson S., Perry R., Blanchard K., Linsell L. Effectiveness of a three-day communication skills course in changing nurses’ communication skills with cancer patients: a randomised controlled trial. Palliative Medicine 2008: 22(4); 365-375.
  45. Wilkinson S., Linsell L., Perry R., Blanchard K. Communication skills training for nurses working with patients with heart disease. British journal of Cardiac Nursing 2008: 3(10); 475-481.
  46. Linsell L., Dawson J., Zondervan K., Rose P., Randall T., Fitzpatrick R., Carr A. Prevalence and incidence of adults consulting for shoulder conditions in primary care; patterns of diagnosis and referral. Rheumatology 2006: 45(2); 215-221.
  47. Linsell L., Dawson J., Zondervan K., Rose P., Randall T., Carr A., Fitzpatrick R. Pain and overall health status in older people with hip and knee replacement: a population perspective. Journal of Public Health 2006: 28(3); 267-273.
  48. Newton S., Cousens S., Owusu-Agyei S., Filteau S., Stanely C., Linsell L., Kirkwood B. Vitamin A supplementation does not affect infants' immune responses to polio and tetanus vaccines: a randomised controlled trial. Journal of Nutrition 2005: 135(11); 2669-2673.
  49. Dawson J., Linsell L., Doll H., Zondervan K., Rose P., Carr A., Randall T., Fitzpatrick R. Assessment of the Lequesne index of severity for osteoarthritis of the hip in an elderly population. Osteoarthritis and Cartilage 2005: 13(10); 845-944.
  50. Dawson J., Linsell L., Zondervan K., Rose P., Carr A., Randall T., Fitzpatrick R. Impact of persistent hip or knee pain on overall health status in elderly people: A longitudinal study. Arthritis Care and Research 2005: 53(3); 368-374.
  51. Linsell L., Dawson J., Zondervan K., Rose P., Carr A., Randall T., Fitzpatrick R. Population survey comparing older adults with hip versus knee pain in primary care. British Journal of General  Practice 2005: 55(512); 192-198.
  52. Linsell L., Dawson J., Zondervan K., Rose P., Randall T., Carr A., Fitzpatrick R. Prospective study comparing treatments following first primary care consultation for a symptomatic hip or knee. Family Practice 2004: 21(6); 1-8.
  53. Dawson J., Linsell L., Zondervan K., Rose P., Randall T., Carr A., Fitzpatrick R. Epidemiology of hip and knee pain and its impact on overall health status in older adults. Rheumatology 2004: 43(4); 497-504.
  54. Linsell L., Cousens S., Smith P., Knight R., Zeidler M., Stewart G., de Silva R., Esmonde T., Ward H., Will R. A case-control study of sporadic Creutzfeldt-Jakob disease in the United Kingdom: Analysis of clustering. Neurology 2004: 63(11); 2077-2083.
  55. Singhal A., Parker S., Linsell L., Serjeant G. Energy intake and resting metabolic rate in preschool Jamaican children with homozygous sickle cell disease. American Journal of Clinical Nutrition 2002: 75(6); 1093-1097.
  56. Cousens S., Linsell L., Smith P., Chandrakumar M., Wilesmith J., Knight R., Zeidler M., Stewart G., Will R. Geographical distribution of variant CJD in the UK (excluding Northern Ireland). Lancet 1999: 353(9146); 18-21.