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Milestone for Frozen Embryo Transfer – Latest HFEA Data

The Human Fertilisation and Embryology Authority (HFEA) data shows live birth rates for frozen embryo transfer rising above fresh embryo transfer in the latest published report.

The success rates for frozen embryo transfer have steadily been improving for frozen embryo transfer and now exceed fresh embryo transfer live birth rates; which the HFEA has described as an ‘important milestone in the development of IVF’. The latest 2016 data shows a live birth rate per embryo transfer of 22% for frozen, compared to 21% for fresh transfers.

Please see the full report for further details.

Frozen Embryo Transfer Lowers Risk of OHSS

New research comparing fresh and frozen embryo transfer by Shi, Y. et. al. (2018) has found that live birth rates are equivalent between the two types of embryo transfer but that frozen embryo transfer significantly lowers the risk of ovarian hyperstimulation syndrome (OHSS).

In this multi-centre randomised controlled trial, 2157 who were undergoing their first IVF were randomly allocated to receive either fresh or frozen embryo transfer. The live birth rate did not differ significantly between the two groups. However, frozen embryo transfer resulted in significantly lower risk of OHSS than fresh embryo transfer (0.6% vs 2.0% relative risk). The risk of other adverse maternal and neonatal outcomes did not differ significantly between the 2 groups.

For more details you can read the full article in The New England Journal of Medicine.

Research indicates frozen embryo transfer is associated with a lower risk of ectopic pregnancy

Research by Zhang et al (2017) compared the risk of ectopic pregnancy in fresh and frozen thawed embryo cycles. A retrospective study was conducted and a total of 69, 756 embryo transfer cycles were analysed, including 45, 960 fresh cycles and 23, 796 frozen cycles. Frozen thawed embryo transfer is associated with a lower incidence of ectopic pregnancy per clinical pregnancy. Within frozen thawed embryo transfer cycles, blastocyst transfer shows a significantly lower risk of ectopic pregnancy in comparison with day 3 cleavage embryo transfer.

For more information, please see the Sage Journal article

Congratulations to the Guy’s Team – 1000th Consent

Guys team celebrating the 1000th E-Freeze consent

Many congratulations to our team at Guy’s on the 1000th Consent to E-Freeze and also for a fantastic month of recruitment in November.

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This study is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme (Reference Number 13/115/82). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.