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E-Freeze trial protocol published in Reproductive Health

E-Freeze is a multi-centre randomised controlled trial being conducted in the UK. It compares fresh embryo transfer with frozen thawed embryo transfer for couples undergoing their first, second or third round of fertility treatment. 

The main aim of E-Freeze is to understand if having a fresh or thawed embryo transfer makes any difference in the chance of having a healthy baby.

The study protocol for E-Freeze has been published in the BioMedCentral Reproductive Health journal. You can find it here.

E-Freeze countdown to the 1500th consent!

Congratulations to all our sites who have consented nearly 1500 couples. As a thank you, we will be providing a small gift to the centre that consents the 1500th couple. Thank you for all your support.


What’s it like taking part in E-Freeze?

To find out a bit more about what it is like taking part in E-Freeze, you can hear Julie talking about her experience on our new parent podcast. Please visit the website for more details:

HFEA Guidance on Fertility Add-Ons

The HFEA (Human Fertilisation & Embryo Authority) have created a traffic light guidance system on additional fertility treatments sometimes offered in clinics and current evidence about how effective they are.

The guidance includes information on embryo freezing; they highlight that early results for embryo freezing are promising, and that some research suggests that pregnancy rates may be improved, but that more research into freezing is required. The E-Freeze trial is helping to provide this evidence as noted by the HFEA. Well done E-Freeze!

More information about treatment add-ons can be found on the HFEA website.

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This study is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme (Reference Number 13/115/82). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.