Associate Professor Ed Juszczak BSc(Hons), MSc, CStat CSci

Associate Professor - Director, NPEU Clinical Trials Unit


Ed Juszczak graduated in Applied Statistics from Sheffield City Polytechnic in 1992, and obtained a Masters degree (MSc) in Medical Statistics from the London School of Hygiene & Tropical Medicine a year later. He then spent 5 years in the Information & Statistics Division of the NHS in Scotland developing an expertise in the design and analysis of case control and cohort studies. In 1998 he joined the Centre for Statistics in Medicine, and as Senior Medical Statistician headed a small dedicated team of statisticians supporting clinical research, predominantly randomised controlled trials (RCTs) and teaching medical statistics to non-statisticians.

Subsequently Ed joined the National Perinatal Epidemiology Unit in September 2007 as Head of Trials, where he oversees a Clinical Trials Unit running a portfolio of typically around 18 neonatal and maternal clinical trials at various stages of completion. He has considerable experience in the design, conduct, analysis and reporting of RCTs, with a particular interest in multi-arm trials and the use of statistics in the areas of neonatology, paediatrics, mental health and surgery. Ed sits on several data monitoring and trial steering committees and in 2007 was conferred the title 'University Research Lectureship' by the University of Oxford, followed in 2010 by the award of Chartered Scientist (CSci) by the Science Council.

Subsequently, Ed became the representative for Clinical Trials Units on the National Institute for Health Research Medicines for Children Research Network Neonatal Clinical Study Group, an executive member of the National Reproductive Health Research Network Clinical Study Group in Fetal Medicine and a Steering Group member of the UKCRC network registered CTU Statisticians Working Group.

In April 2013, Ed was designated Director of the NPEU CTU, and in the summer of 2013, Ed joined the NIHR HTA Commissioning Board. More recently, in October 2014, Ed was awarded the title of Associate Professor, and in November 2016, he joined the newly established NIHR HTA General Board until his tenure ended in 2018.

Presently he sits on the Northern Ireland Clinical Trials Unit Advisory Group and the board of the Oxford Brain Health Clinical Trials Unit.

For news about the latest research aimed at protecting newborn babies from Necrotising Enterocolitis (a life-threatening bowel problem), funded by Action Medical Research and led by Ed and collaborators from the University of Southampton click here.



  • Chappell LC, Green M, Marlow N, Sandall J, Hunter R, Robson S, Bowler U, Chiocchia V, Hardy P, Juszczak E, Linsell L, Placzek A, Brocklehurst P, Shennan A. Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial). Trials. 2019;20(1):85.
  • Clarke P, Craig JV, Wain J, Tremlett C, Linsell L, Bowler U, Juszczak E, Heath PT. Safety and efficacy of 2% chlorhexidine gluconate aqueous versus 2% chlorhexidine gluconate in 70% isopropyl alcohol for skin disinfection prior to percutaneous central venous catheter insertion in preterm neonates: the ARCTIC randomised-controlled feasibility trial protocol. BMJ open. 2019;9(2):e028022.
  • Gale C, McGuire W, Juszczak E. Randomised Controlled Trials for Informing Perinatal Care. Neonatology. 2019;10.1159/000499881.
  • Griffiths J, Jenkins P, Vargova M, Bowler U, Juszczak E, King A, Linsell L, Murray D, Partlett C, Patel M, Berrington J, Dorling J, Embleton ND, Heath PT, Oddie S, McGuire W, Ainsworth S, Boyle E, Clarke P, Craig S, Johnson K, Mactier H, Scorrer T, Ledwidge M, Story I, Holder G, Ohadike P, Ellis S, Vaikute R, Gowda G, Yates H, Garg S, Pilling E, Roehr C, Batra D, Gibson D, Johnson M, Kumar Y, Bartle D, Peters C, Quine D, Gupta R, Matthes J, Kennea N, Reynolds P, Geethanath R, Janakiraman S, Vasu V, Manjunatha CM. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. The Lancet. 2019;393(10170):423-33.
  • Harrington RA, Scarborough P, Hodgkins C, Raats MM, Cowburn G, Dean M, Doherty A, Foster C, Juszczak E, Ni Mhurchu C, Winstone N, Shepherd R, Timotijevic L, Rayner M. A Pilot Randomized Controlled Trial of a Digital Intervention Aimed at Improving Food Purchasing Behaviour: The Front-of-Pack Food Labels Impact on Consumer Choice Study. JMIR Form Res. 2019;3(2):e9910.
  • Juszczak E, Altman DG, Hopewell S, Schulz K. Reporting of Multi-Arm Parallel-Group Randomized Trials: Extension of the CONSORT 2010 Statement. JAMA. 2019;321(16):1610-20.
  • Knight M, Chiocchia V, Partlett C, Rivero-Arias O, Hau X, Hinshaw K, Tuffnell D, Linsell L, Juszczak E, on behalf of the ANODE collaborative group. Prophylactic antibiotics in the prevention of infection after operative vaginal delivery (ANODE): a multicentre randomised controlled trial. The Lancet. 2019;393(10189):2395-403.
  • Maheshwari A, Bhattacharya S, Bowler U, Brison D, Child T, Cole C, Coomarasamy A, Cutting R, Harbottle S, Hardy P, Juszczak E, Khalaf Y, Kurinczuk JJ, Lavery S, Lewis-Jones C, Macklon N, Raine-Fenning NJ, Rajkohwa M, Scotland G, Troup S. Study protocol: E-freeze - freezing of embryos in assisted conception: a randomised controlled trial evaluating the clinical and cost effectiveness of a policy of freezing embryos followed by thawed frozen embryo transfer compared with a policy of fresh embryo transfer, in women undergoing in vitro fertilisation. Reproductive Health. [journal article]. 2019;16(1):81.


  • Askie LM, Darlow BA, Finer N, Schmidt B, Stenson B, Tarnow-Mordi W, Davis PG, Carlo WA, Brocklehurst P, Davies LC, Das A, Rich W, Gantz MG, Roberts RS, Whyte RK, Costantini L, Poets C, Asztalos E, Battin M, Halliday HL, Marlow N, Tin W, King A, Juszczak E, J. MC, Doyle LW, Gebski V, Hunter KE, Simes RJ, Collaboration ftNOPM-aN. Association between oxygen saturation targeting and death or disability in extremely preterm infants in the neonatal oxygenation prospective meta-analysis collaboration. JAMA. 2018;319(21):2190-201.
  • Brocklehurst P, Field D, Greene K, Juszczak E, Kenyon S, Linsell L, Mabey C, Newburn M, Plachcinski R, Quigley M, Steer P, Schroeder L, Rivero-Arias O. Computerised interpretation of the fetal heart rate during labour: a randomised controlled trail (INFANT). Health Technology Assess. 2018;22(9):1-186.
  • Chappell LC, Chambers J, Dixon PH, Dorling J, Hunter R, Bell JL, Bowler U, Hardy P, Juszczak E, Linsell L, Rounding C, Smith A, Williamson C, Thornton JG. Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES). Trials. [journal article]. 2018;19(1):657.
  • Fleck BW, Williams C, Juszczak E, Cocker K, Stenson BJ, Darlow BA, Dai S, Gole GA, Quinn GE, Wallace DK, Ells A, Carden S, Butler L, Clark D, Elder J, Wilson C, Biswas S, Shafiq A, King A, Brocklehurst P, Fielder AR, Group BIRIDA. An international comparison of retinopathy of prematurity grading performance within the Benefits of Oxygen Saturation Targeting II trials. Eye. [Clinical Study]. 2018;32(1):74-80.
  • Hartley C, Moultrie F, Hoskin A, Green G, Monk V, Bell JL, King AR, Buckle M, van der Vaart M, Gursul D, Goksan S, Juszczak E, Norman JE, Rogers R, Patel C, Adams E, Slater R. Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial. The Lancet. 2018;392(10164):2595-605.
  • Juszczak E, Gupta S. Continued uncertainty regarding treatment of patent ductus arteriosus in premature infants and the role of clinical trials. Seminars in Fetal and Neonatal Medicine. 2018;23(4):267-72
  • Knight M, Mottram L, Gray S, Partlett C, Juszczak E. Prophylactic antibiotics for the prevention of infection following operative vaginal delivery (ANODE): study protocol for a randomised controlled trial. Trials. [journal article]. 2018;19(1):395.
  • Kwakkenbos L, Imran M, McCord KA, Sampson M, Fröbert O, Gale C, Hemkens LG, Langan SM, Moher D, Relton C, Zwarenstein M, Benchimol EI, Boutron I, Campbell MK, Erlinge D, Jawad S, Ravaud P, Rice DB, Sauve M, van Staa TP, Thabane L, Uher R, Verkooijen HM, Juszczak E, Thombs BD. Protocol for a scoping review to support development of a CONSORT extension for randomised controlled trials using cohorts and routinely collected health data. BMJ open. 2018;8(8):e:025266.
  • Kwakkenbos L, Juszczak E, Hemkens LG, Sampson M, Fröbert O, Relton C, Gale C, Zwarenstein M, Langan SM, Moher D, Boutron I, Ravaud P, Campbell MK, Mc Cord KA, van Staa TP, Thabane L, Uher R, Verkooijen HM, Benchimol EI, Erlinge D, Sauvé M, Torgerson D, Thombs BD. Protocol for the development of a CONSORT extension for RCTs using cohorts and routinely collected health data. Research Integrity and Peer Review. [journal article]. 2018;3(1):9.
  • Marshall A, Sadarangani M, Scrivens A, Williams R, Yong J, Bowler U, Linsell L, Chiocchia V, Adams E, Juszczak E, Roehr C. Champagne and bloody taps: can we improve the success rate of neonatal lumbar punctures? Infant. 2018;14(6):224-6.
  • Stenson BJ, Donoghoe M, Brocklehurst P, Davis PG, Juszczak E, Marschner IC, Simes J, Tarnow-Mordi WO. Pulse Oximeter Saturation Targeting and Oximeter Changes in the Benefits of Oxygen Saturation Targeting (BOOST)-II Australia and BOOST-II UK Oxygen Trials. The Journal of Pediatrics. 2018;204:301-4.e2.
  • Griffiths J, Jenkins P, Vargova M, Bowler U, Juszczak E, King A, Linsell L, Murray D, Partlett C, Patel M, Berrington J, Embleton N, Dorling J, Heath PT, McGuire W, Oddie S. Enteral lactoferrin to prevent infection for very preterm infants: the ELFIN RCT. Health Technology Assessment. 2018;22(74):1-60.


  • Abbott J, Berrington J, Bowler U, Boyle E, Dorling J, Embleton N, Juszczak E, Leaf A, Linsell L, Johnson S, McCormick K, McGuire W, Roberts T, Stenson B. The Speed of Increasing milk Feeds: a randomised controlled trial. BMC Pediatr. [journal article]. 2017;17(1):39.
  • Brocklehurst P, Field D, Greene K, Juszczak E, Keith R, Kenyon S, Linsell L, Mabey C, Newburn M, Plachcinski R, Quigley M, Schroeder E, Steer P. Computerised interpretation of fetal heart rate during labour (INFANT): a randomised controlled trial. The Lancet. 2017;389(10080):1719-29.
  • Brocklehurst P, Field D, Greene K, Juszczak E, Keith R, Kenyon S, Linsell L, Mabey C, Newburn M, Plachcinski R, Quigley M, Schroeder E, Steer P. Computerised Interpretation of Fetal Heart Rate During Labour (INFANT): A Randomised Controlled Trial. Obstetrical and Gynecological Survey. Obstet Gynecol Surv. 2017;72(9):517-9.
  • Brocklehurst P, Field D, Greene K, Juszczak E, Keith R, Kenyon S, Linsell L, Mabey C, Newburn M, Plachcinski R, Quigley M, Schroeder E, Steer P, The INFANT Collaborative Group. Computerised Interpretation of Fetal Heart Rate During Labour (INFANT): A Randomised Controlled Trial. Obstet Gynecol Surv. 2017;72(9):517-9.
  • Brocklehurst P, Field D, Juszczak E, Kenyon S, Linsell L, Newburn M, Plachcinski R, Quigley M, Schroeder L, Steer P. The INFANT Trial. The Lancet. 2017;390(10029):28.
  • Brocklehurst P, Field DJ, Juszczak E, Kenyon S, Linsell L, Newburn M, Plachcinski R, Quigley M, Schroeder L, Steer P. The INFANT trial. The Lancet. 2017;390(10089):28.
  • Embleton ND, Berrington JE, Dorling J, Ewer AK, Juszczak E, Kirby JA, Lamb CA, Lanyon CV, McGuire W, Probert CS, Rushton SP, Shirley MD, Stewart CJ, Cummings SP. Mechanisms Affecting the Gut of Preterm Infants in Enteral Feeding Trials. Frontiers in Nutrition. [Original Research]. 2017;4(14).
  • Millar M, Seale J, Greenland M, Hardy P, Juszczak E, Wilks M, Panton N, Costeloe K, Wade WG. The Microbiome of Infants Recruited to a Randomised Placebo-controlled Probiotic Trial (PiPS Trial). EBioMedicine. 2017;20:255-62.
  • Reynolds RM, Denison FC, Juszczak E, Bell JL, Penneycard J, Strachan MWJ, Lindsay RS, Alexander CI, Love CDB, Whyte S, Mackenzie F, Stenson B, Norman JE. Glibenclamide and metformin versus standard care in gestational diabetes (GRACES): a feasibility open label randomised trial. BMC Pregnancy Childbirth. [journal article]. 2017;17(1):316.
  • Williams FLR, Ogston S, Hume R, Watson J, Stanbury K, Willatts P, Boelen A, Juszczak E, Brocklehurst P. Supplemental Iodide for Preterm Infants and Developmental Outcomes at 2 Years: An RCT. Pediatrics. 2017;139(5).
  • Bick D, Briley A, Brocklehurst P, Hardy P, Juszczak E, Lynch L, MacArthur C, Moore P, Nolan M, Rivero-Arias O, Sanders J, Shennan A, Wilson M. A multicentre, randomised controlled trial of position during the late stages of labour in nulliparous women with an epidural: clinical effectiveness and an economic evaluation (BUMPES). 2017 Contract No.: 65.


  • Costeloe K, Hardy P, Juszczak E, Wilks M, Millar MR, Probiotics in Preterm Infants Study Collaborative G. Bifidobacterium breve BBG-001 in very preterm infants: a randomised controlled phase 3 trial. Lancet. 2016;387(10019):649-60.
  • Costeloe KL, Bowler U, Brocklehurst P, Hardy P, Heal P, Juszczak E, King A, Panton N, Stacey F, Whiley A, Wilks M, Millar MR. A randomised controlled trial of the probiotic Bifidobacterium breve BBG-001 in preterm babies to prevent sepsis, necrotising enterocolitis and death: the Probiotics in Preterm infants (PiPS) trial. Health Technol Assess. 2016;20(66).
  • Gale C, Juszczak E. A paediatrician's guide to clinical trials units. Archives of Disease in Childhood - Education & Practice Edition. 2016;101(5):265-7.
  • Millar MR, Seale J, Turton J, Wilks M, Costeloe K, Woodford N, Juszczak E, Whiley A, Panton N, Wareham DW. ESBL-producing Enterobacteriaceae in 24 neonatal units and associated networks in the south of England: no clustering of ESBL-producing Escherichia coli in units or networks. J Antimicrob Chemother. 2016;71(5):1174-7.
  • Moreton RB, Fleck BW, Fielder AR, Williams CA, Butler L, Wilson C, Cocker K, Juszczak E, King A, Stenson B, Brocklehurst P. The effect of oxygen saturation targeting on retinal blood vessel growth using retinal image data from the BOOST-II UK Trial. Eye (Lond). 2016;30(4):577-81.
  • Slater R, Hartley C, Moultrie F, Adams E, Juszczak E, Rogers R, Norman J, Patel C, Stanbury K, Hoskin A, Green G, null n. A blinded randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants: Trial protocol [version 1; referees: awaiting peer review]. 2016;1(7).


  • Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, Strohm B, Tusor N, Edwards AD. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. The Lancet Neurology. 2015;15(2):145-53.
  • Howard R, McShane R, Lindesay J, Ritchie C, Baldwin A, Barber R, Burns A, Dening T, Findlay D, Holmes C, Jones R, Jones R, McKeith I, Macharouthu A, O'Brien J, Sheehan B, Juszczak E, Katona C, Hills R, Knapp M, Ballard C, Brown RG, Banerjee S, Adams J, Johnson T, Bentham P, Phillips PPJ. Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses. The Lancet Neurology. 2015;14(12):1171-81.
  • Juszczak E, Gupta S. The Baby-OSCAR trial: rationale and practicalities. Infant. 2015;11(6):184-6.
  • Parekh SA, Field DJ, Johnson S, Juszczak E. Accounting for deaths in neonatal trials: is there a correct approach? Arch Dis Child Fetal Neonatal Ed. 2015;100(3):F193-7.


  • Azzopardi D, Strohm B, Marlow N, Brocklehurst P, Deierl A, Eddama O, Goodwin J, Halliday HL, Juszczak E, Kapellou O, Levene M, Linsell L, Omar O, Thoresen M, Tusor N, Whitelaw A, Edwards AD, Group TS. Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med. 2014;371(2):140-9.
  • Kempley S, Gupta N, Linsell L, Dorling J, McCormick K, Mannix P, Juszczak E, Brocklehurst P, Leaf A, ADEPT Trial Collaborative Group. Feeding infants below 29 weeks' gestation with abnormal antenatal Doppler: analysis from a randomised trial. . Arch dis Child Neonatal Ed. 2014;99(1):F6-F11.
  • Williams F, Hume R, Ogston S, Brocklehurst P, Morgan K, Juszczak E. A Summary of the Iodine Supplementation Study Protocol (I2S2): A UK Multicentre Randomised Controlled Trial in Preterm Infants. Neonatology. 2014;105(4):282-9.
  • Williams F, Hume R, Ogston S, Brocklehurst P, Morgan K, Juszczak E, team IS. A summary of the iodine supplementation study protocol (I2S2): a UK multicentre randomised controlled trial in preterm infants. Neonatology. 2014;105(4):282-9.


  • Barber V, Linsell L, Locock L, Powell L, Shakeshaft C, Lean K, Colman J, Juszczak E, Brocklehurst P. Electronic fetal monitoring during labour and anxiety levels in women taking part in a RCT. British Journal of Midwifery. 2013;21(6):394-403.;article=BJM_21_6_394_403
  • BOOST II United Kingdom Collaborative Group, BOOST II Australia Collaborative Group, BOOST II New Zealand Collaborative Group, Stenson BJ, Tarnow-Mordi WO, Darlow BA, Simes J, Juszczak E, Askie L, Battin M, Bowler U, Broadbent R, Cairns P, Davis PG, Deshpande S, Donoghoe M, Doyle L, Fleck BW, Ghadge A, Hague W, Halliday HL, Hewson M, King A, Kirby A, Marlow N, Meyer M, Morley C, Simmer K, Tin W, Wardle SP, Brocklehurst P. Oxygen saturation and outcomes in preterm infants. N Engl J Med. 2013;368(22):2094-104.
  • Field D, Juszczak E, Linsell L, Azzopardi D, Cowan F, Marlow N, Edwards D, Group NSC. Neonatal ECMO study of temperature (NEST): a randomized controlled trial. Pediatrics. 2013;132(5):e1247-56.
  • Group CC, Abalos E, Oyarzun E, Addo V, Sharma JB, Matthews J, Oyieke J, Masood SN, El Sheikh MA, Brocklehurst P, Farrell B, Gray S, Hardy P, Jamieson N, Juszczak E, Spark P. CORONIS - International study of caesarean section surgical techniques: the follow-up study. BMC Pregnancy Childbirth. 2013;13:215.
  • The CORONIS Collaborative Group, Ablos E, Addo V, Brocklehurst P, El Sheikh M, Farrell B, Gray S, Hardy P, Juszczak E, Mathews JE, Masood SN, Oyarzun E, Oyieke J, Sharma JB, Spark P. Caesarean section surgical techniques (CORONIS): a fractional, factorial, unmasked, randomised controlled trial. The Lancet. 2013;382(9888):234-48.


  • Azzopardi D, Strohm B, Linsell L, Hobson A, Juszczak E, Kurinczuk JJ, Brocklehurst P, Edwards AD, on behalf of the UKTCR. Implementation and Conduct of Therapeutic Hypothermia for Perinatal Asphyxial Encephalopathy in the UK – Analysis of National Data. PLoS One. 2012;7(6):e38504.
  • Leaf A, Dorling J, Kempley S, McCormick K, Mannix P, Linsell L, Juszczak E, Brocklehurst P. Early or Delayed Enteral Feeding for Preterm Growth-Restricted Infants: A Randomized Trial. Pediatrics. 2012;129(5):e1260-8.


  • Johnston ED, Boyle B, Juszczak E, King A, Brocklehurst P, Stenson BJ. Oxygen targeting in preterm infants using the Masimo SET Radical pulse oximeter. Arch Dis Child Fetal Neonatal Ed. 2011;96(6):F429-F33.
  • Morgan K, Juszczak E, Bowler U. A practical solution to 'Continuing Care site' issues in neonatal clinical trials - a pragmatic approach to regulatory and research governance review. Trials. 2011;12(Supp 1):A37.
  • The INIS Collaborative Group, Brocklehurst P, Farrell B, King A, Juszczak E, Darlow B, Haque K, Salt A, Stenson B, Tarnow-Mordi W. Treatment of Neonatal Sepsis with Intravenous Immune Globulin. N Engl J Med. 2011;365(13):1201-11.


  • Edwards AD, Brocklehurst P, Gunn AJ, Halliday H, Juszczak E, Levene M, Strohm B, Thoresen M, Whitelaw A, Azzopardi D. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. Br Med J. 2010;340:c363.
  • Field D, Firmin R, Azzopardi D, Cowan F, Juszczak E, Brocklehurst P, the NEST Study Group. Neonatal ECMO Study of Temperature (NEST) - a randomised controlled trial. BMC Pediatr. 2010;10(1):24.
  • Zhang W-H, Deneux-Tharaux C, Brocklehurst P, Juszczak E, Joslin M, Alexander S. Effect of a collector bag for measurement of postpartum blood loss after vaginal delivery: cluster randomised trial in 13 European countries. Br Med J. 2010;340:c293.


  • Azzopardi D, Strohm B, Edwards AD, Halliday H, Juszczak E, Levene M, Thoresen M, Whitelaw A, Brocklehurst P. Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial. Arch Dis Child Fetal Neonatal Ed. 2009;94(4):F260-F4.
  • Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, Kapellou O, Levene M, Marlow N, Porter E, Thoresen M, Whitelaw A, Brocklehurst P. Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy. N Engl J Med. 2009;361(14):1349-58.